The Cellular Senescence Network (SenNet) Program, supported by the NIH Common Fund, was established to comprehensively identify and characterize the differences in senescent cells across the body, across various states of human health, and across the lifespan. SenNet is providing publicly accessible atlases of senescent cells, the differences among them, and the molecules they secrete, using data collected from multiple human and model organism tissues. To identify and characterize these rare cells, SenNet is developing innovative tools and technologies that build upon previous advances in single cell analysis, such as those from the Common Fund’s Human Biomolecular Atlas Program. Lastly, SenNet is uniting cellular senescence researchers by developing common terms and classifications for senescent cells.
New Members: Please make sure you register for an account on SenNet and direct all questions to
help@sennetconsortium.org.
You can also visit our Frequently Asked Questions page.
View the “Navigating the SenNet Consortium Website” video above for a comprehensive tour of how to access public SenNet resources.
View the “Registering as a SenNet Consortium Member” video above to receive instructions on how to join the SenNet Consortium.
The SenNet Interview Series
The SenNet Interview Series is an anthology of video interviews profiling the researchers contributing to the SenNet Consortium. In these interviews, scientists offer candid insights into their ongoing senescence research, initiatives within the Consortium, and the ways in which SenNet functions as both a community and a resource for senescence researchers across the U.S.
The scientists interviewed discuss their backgrounds and what initially drew them to the field of senescence research. They also share their learned experience for junior investigators and students interested in this field.
All published interviews can be watched here.
Consider subscribing to our YouTube page to be notified as soon as new interviews go live.
News
At the Knowledge Graphs symposium at the Bio-IT World Conference & Expo, SenNet PI Jonathan C. Silverstein presented the UBKG Knowledge Graph (KG) that serves as data backend for both the SenNet and HuBMAP Data Portal. PI Katy Börner presented the Human Reference Atlas KG that serves as data backend for the HRA Portal. (April 2025).
“MRI detection of senescent cells in porcine knee joints with a β-galactosidase responsive Gd-chelate” is in press with Nature Publishing Group (NPJ) Imaging, featuring the research of SenNet scientists. Check back for a link to the publication soon! (April 2025).
“Human BioMolecular Atlus Program (HuBMAP): 3D Human Reference Atlas Construction and Usage” was published in Nature Methods on March 13, 2025, featuring the work of several SenNet authors. Read here. Additional supporting information can be found here. (March 2025).
The HDIVE Lab at Harvard Medical School is pleased to announce “VUES on Spatial Biology – The Future of 3D Tissue Maps” on March 11, 2025. This in person event will be held at Harvard Medical School. Registration is free, and more information can be found here. (March 2025).
The 2025 HuBMAP JumpStart Fellowship is now accepting applications, offering junior investigators working on human atlasing projects the opportunity to take a leadership role in conducting synergistic, collaborative research projects within the HuBMAP Consortium. Apply and find more info here! (February 2025).
The Human Reference Atlas is hosting a 24-hour online webinar titled “What is a Multiscale Human,” starting at 12:00pm on Dec. 14. Visit this page to register and attend. (December 2024).
Thomas Höllt, PhD from the Delft University of Technology will be speaking on “Visual Analytics for Spatially resolved High-Dimensional Data – Methods and Applications in Biology.” Register to attend here. (December 2024).
SenNet research sites at Indiana University and Columbia University collaborate on a senescent cell VR demo, featuring Andreas Bueckle, PhD, and Hemali Phatnani, PhD. Click to view here. (December 2024).
Join the NHLBI for a virtual workshop on November 7-8, 2024, from 10:30am-4:00pm EST, focused on progenitor resilience and the early onset of chronic lung diseases. More details and registration can be found here. (November 2024).
VUES Webinar: “Democratizing the analysis and visualization of omics datasets using Multi-Dimensional Viewer” with speaker Stephen Taylor, PhD. Presented on 10/15/24 at 11:00am EST. More info and registration here. (October 2024).